Endocrine Abstracts

The ubiquitin-proteasome cascade has been described as a critical factor in adipocyte biology, insulin signaling and obesity, but the function of Nedd8, the ubiquitin-like protein with the closest homology to ubiquitin, remains unknown. Using 3T3-L1 preadipocyte cells, we found that MLN-4924, a specific neddylation inhibitor, blocks adipocyte differentiation. Screening for signaling and transcriptional factors driving adipogenesis, we found that neddylation blockade inhibits t...